https://hibm.org/hrg/hrgwww/ 2026-05-02T02:41:42+00:00 https://hibm.org/hrg/hrgwww/ https://hibm.org/hrg/hrgwww/_media/wiki:dokuwiki.svg text/html 2009-03-24T18:26:53+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:developing_therapy?rev=1237919213&do=diff Developing Therapy Most people don't know how scientists (biomedical investigators) go about developing a treatment for an untreatable disease. We thought it would be a good idea to briefly outline the steps for those interested to learn more about the process. Although the process is super-simplified here, it should be a good starting point: text/html 2009-03-21T19:36:12+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:is_there_a_treatment?rev=1237664172&do=diff Is There a Treatment? Currently, there are no effective treatments for HIBM. Researchers at Hadassah, USC, UCLA, UCSD, Johns Hopkins University, Canada, NIH, and Japan are contributing towards finding an effective treatment. You may also wish to look at text/html 2009-03-21T19:13:32+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:obtain_biomaterials_specific_to_hibm?rev=1237662812&do=diff Obtain Biomaterials Specific For HIBM Following biomaterials are currently available. * GNE clones, including wildtype, HIBM, and Sialuria forms. * Mouse model bearing the GneM712T/M712T genotype. * Polyclonal chicken anti-GNE, affinity purified. text/html 2011-05-15T22:26:32+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:research_articles?rev=1305498392&do=diff Research Articles Not all published papers are listed here. If you believe an article of significant importance should be listed, please contact us. Thank you. 2010 - 2015 * 2011 Nemunaitis G, Jay CM, Maples PB, Gahl WA, Huizing M, Yardeni T, Tong AW, Phadke AP, Pappen BO, Bedell C, Allen H, Hernandez C, Templeton NS, Kuhn J, Senzer N, Nemunaitis J. Hereditary Inclusion Body Myopathy: Single Patient Response to Intravenous Dosing of GNE Gene Lipoplex. Hum Gene Ther. 2011 Apr 25. [Epub a… text/html 2009-03-22T00:50:44+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:research_collaboration?rev=1237683044&do=diff Research Collaboration We welcome and encourage collaboration towards development of therapy for HIBM. Please do not hesitate to contact us for further information. See a list of our past successful collaborations. text/html 2012-08-03T20:51:55+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:spectrum_ibm2_mutations?rev=1344027115&do=diff Spectrum of IBM2 Mutations GNE Mutations Associated with IBM2/DMRV/HIBM/QSM, updated 8/03/2012. Table 1 is organized by reported patient(s). Table 2 is organized by the specific mutation. Mutations are reported using “E[Exon number]:” or “I[Intron number] text/html 2021-08-19T20:50:00+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:start?rev=1629406200&do=diff Information For Doctors HRG is a unique laboratory involved in both clinical testing and collaborative biomedical research towards developing an effective therapy for HIBM. Since HIBM is an ultra-orphan disorder, we strongly encourage collaborative research and philanthropic efforts through text/html 2021-08-19T20:52:23+00:00 Anonymous (anonymous@undisclosed.example.com) https://hibm.org/hrg/hrgwww/fordoctors:what_is_hibm?rev=1629406343&do=diff What is HIBM or GNE Myopathy? Hereditary Inclusion Body Myopathies (HIBM) are a group of muscle wasting disorders, which are uncommon in the general world population. An autosomal recessive form of HIBM is known as GNE Myopathy, IBM2, which is a common genetic disorder amongst people of Iranian-Jewish descent. IBM2 has also been identified in other minorities throughout the world. Patients of Asian (Japanese and others), European, and South American origin, as well as Muslim patients in the Mid…